Evidence-based clinical protocols and decision support tools developed by the NNH team to guide management of common nephrology conditions.
Diagnosis, empiric antibiotic selection, and management of peritoneal dialysis-associated peritonitis based on ISPD guidelines. Includes organism-specific treatment pathways and catheter exit site infection protocols.
Open ProtocolProcedure-specific antibiotic prophylaxis recommendations for PD patients undergoing dental work, colonoscopy, upper endoscopy with PEG, gynecologic procedures, and PD catheter insertion, based on ISPD guidelines.
Open ProtocolESA dose-adjustment calculator for ESKD patients on Aranesp (darbepoetin alfa) or Mircera (methoxy PEG-epoetin beta). Computes projected 28-day hemoglobin change and recommends a new dose level based on a 9×10 hemoglobin/trajectory matrix.
Open ProtocolInteractive stage-based guidance for monitoring and managing calcium, phosphorus, PTH, vitamin D, bone health, and phosphate-lowering therapy in CKD 1–5D, based on the KDIGO 2017 CKD-MBD Guideline Update.
Open ProtocolEvidence-based workflow integrating KDIGO supportive care, Oxford MEST-C risk stratification, and emerging targeted therapies — Nefecon, sparsentan, atrasentan, sibeprenlimab, and iptacopan — with an interactive risk gauge, immunosuppression decision tool, and evidence library.
Open ProtocolEvidence-based workflow for diagnosing and managing gout and hyperuricemia in patients with CKD. Includes urate-lowering therapy selection (allopurinol, febuxostat, pegloticase), CKD-adjusted dosing, target serum urate, acute flare management, and anti-inflammatory prophylaxis during ULT initiation.
Open ProtocolPEXIVAS-based reduced-dose glucocorticoid taper generator for severe ANCA-associated vasculitis (GPA, MPA). Produces a weight-based starting dose, an interactive timeline with actual calendar dates, Athena-ready patient instructions, and optimized prednisone prescriptions with minimum pill burden. Delivers about 40% less cumulative glucocorticoid than standard dosing while remaining noninferior for death or ESKD.
Open ToolInteractive teaching tools for ICU and dialysis nursing, residents, fellows, APPs, and nephrologists. Visual circuit diagrams, mechanism walkthroughs, and bedside calculators built around evidence-based references.
Interactive teaching tool covering all major continuous renal replacement therapy modalities — SCUF, CVVH, CVVHD, CVVHDF, SLED, HVHF, CPFA, CHP, and CPF-PE. Animated circuit diagrams, diffusion vs convection explainer, prescription parameters with effluent dose and filtration fraction calculators, and pearls/pitfalls for the bedside.
Open EducatorClinician-facing 4-hour sodium mass-balance simulator built on the Edelman equation. Differential dx engine, electrolyte-free water clearance gauge, animated Edelman fraction, target-Na inverse solver, ADH-off scenario explorer, and osmotic demyelination risk in one cockpit.
Open EducatorClinician-facing simulator and teaching tool for acid-base disorders. Step-by-step primary disorder identification, expected-compensation calculators, anion gap and delta-delta analysis, mixed-disorder unmasking, and a urine-electrolyte module for non-anion-gap acidosis. Built on Berend (NEJM 2014) and Adrogué/Madias (JASN 2010).
Open EducatorClinician-facing tool for evaluating and managing uremic pruritus in CKD and dialysis patients. Covers differential diagnosis, severity assessment, and an evidence-based treatment ladder (emollients, gabapentinoids, antihistamines, UVB phototherapy, difelikefalin) with CKD-adjusted dosing.
Open EducatorInteractive education module on modern layered renoprotection in CKD. Covers RAAS blockade with ACEi and ARBs, SGLT2 inhibitors, finerenone, GLP-1 receptor agonists, and disease-specific therapies, including mechanisms, landmark trials, sequencing, combination strategy, and safety monitoring.
Open EducatorInteractive teaching modules for hemodialysis nurses, patient care technicians, dialysis unit staff, and the clinicians who train them. In-depth education on dialysis prescription, adequacy, vascular access, and the science behind day-to-day hemodialysis practice.
Interactive education module on Kt/V and dialysis adequacy in in-center hemodialysis. Covers what Kt/V measures, the history of adequacy research from NCDS to the HEMO Study, single-pool versus equilibrated Kt/V (spKt/V vs eKt/V), standardized weekly Kt/V, residual kidney function, and incremental (twice-weekly) hemodialysis.
Open EducatorInteractive physiology lab on peritoneal membrane transport status. Covers what fast and slow transporters are at the membrane level, why solute clearance and ultrafiltration often move in opposite directions, the Peritoneal Equilibration Test (PET), how icodextrin rescues UF in fast transporters, the role of residual kidney function, and how transport status guides PD prescription design.
Open Educator